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HYADENT BG


Description:

The natural promoter of regeneration

Hyaluronic Acid

HA Gel composed of a mixture of cross-linked (1,6%) and natural (0,2%) Hyaluronic Acid

2 x 1.2 ml cylindrical ampulla

Terms of delivery Delivery Is free of charge within 24 hours after funds are credited to your Bank account
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Clinical cases

Periodontal regeneration in deep infrabony defects with CaP/ß-TCP and hyaluronic acid
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Case provided By Prof. Dr. Anton Friedman (Chair and Head Department of Periodontology, School of Dentistry, Faculty of Health, University of Witten, Germany)


Female 35 years non-smoking patient with two singular periodontal defects

Mandibular right first molar with progredient attachment loss and infrabony defects

Baseline assessment: intact papillae; narrow interdental space; no gingival recession

Initial PPD distal 7 mm; BoP+ Initial PPD distal 7 mm; BoP+
HYADENT BG clinical case
Initial PPD mesial 8 mm; BoP+ Initial PPD distal 8 mm; BoP+

Minimally invasive periodontal surgery

M-MIST flap design (Cortellini 2008); infrabony component treated with CaP/ß-TCP + hyaluronic acid (Osopia® + hyaDENT BG®, Regedent Germany)

Mesial 1- to 2-wall defect at 46 from the buccal and the lingual aspect
Mesial 1- to 2-wall defect at 46 from the buccal and the lingual aspect
Mesial 1- to 2-wall defect at 46 from the buccal and the lingual aspect
Distal 1- to 2-wall defect at 46 from the buccal Distal 1- to 2-wall defect at 46 from the buccal
Graft preparation by hydrating Osopia® with HA Graft preparation by hydrating Osopia® with HA

Flap closure and suture

Complete primary tensionless closure of interdental papillae using the CAF principle and modified matrass suture (Laurell et al., 1994)

Suture material: monocryl® 6.0 (Ethicon, Germany)

Buccal view Buccal view
Lingual view Lingual view

Post-op monitoring

Uneventful healing, suture removal at 2 weeks visit

Reported by the patient loss of some particulate material

One week post-op buccal/lingual view
One week post-op buccal/lingual view
One week post-op buccal/lingual view
Two weeks post-op buccal/lingual view
Two weeks post-op buccal/lingual view
Two weeks post-op buccal/lingual view

Evaluation of regenerative result 12 months post surgery

Clinical examination: no gingival recession; no loss of interdental papillae

Assessment of PPD and BoP tendency

One week post-op buccal/lingual view
One week post-op buccal/lingual view
One week post-op buccal/lingual view
Two weeks post-op buccal/lingual view
Two weeks post-op buccal/lingual view
Two weeks post-op buccal/lingual view

Radiographic assessment of treatment sequence

X-ray documented transition from bilateral deep infrabony defect towards complete defect resolution 1 year after surgery

Baseline periapical x-ray Baseline periapical x-ray
Post-op periapical control Post-op periapical control
1-year post-op control 1-year post-op control
Coverage of Miller class 3 (RT2 Class A+) recession with CTG + HA using modified Tunneling technique
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Case Provided By Prof. Dr. Anton Friedman (Chair and Head Department of Periodontology, School of Dentistry, Faculty of Health, University of Witten, Germany)


Baseline situation

Non-smoking female aging 45 years

History of active periodontitis therapy / ≈ 10 years of SPT

Tooth 12 disclosed recession >3mm on the buccal and ≈ 2mm at mesial aspect

Generalized loss of papillae across maxillary anterior mention

Interest in harmonizing the gingival contour due to the burden of gummy smile

Baseline

Soft tissue handling avoiding vertical access

Sulcular incisions Sulcular incisions
Submucosal tunneling preparation lifting papillae on both sides of the defect Submucosal tunneling preparation lifting papillae on both sides of the defect

Connective tissue graft (CTG) handling

CTG retrieved from the palate using trap-door preparation CTG retrieved from the palate using trap-door preparation
Sliding suture for moving the graft into the tunnel Sliding suture for moving the graft into the tunnel

HA application

HA (hyaDENT BG, Regedent, Germany) is applied using sterile carpule topically at the donor and into the tunnel at recipient site before suture

HA (hyaDENT BG, Regedent, Germany) is applied using sterile carpule topically at the donor and into the tunnel at recipient site before suture
HA (hyaDENT BG, Regedent, Germany) is applied using sterile carpule topically at the donor and into the tunnel at recipient site before suture

Suture fixation

Suture with 5.0 PTFE monofilament suture (BioTex, Regedent, Germany) Suture with 5.0 PTFE monofilament suture (BioTex, Regedent, Germany)
Slinging suture and modified vertical mattress suture Slinging suture and modified vertical mattress suture

Post-op follow-up

Day 7 visit - uncomplicated healing

Day 7 visit - uncomplicated healing
Day 7 visit - uncomplicated healing

Post-op follow-up

Day 12 - no signs of swelling, nice coloration of the gingiva

Day 12 - no signs of swelling, nice coloration of the gingiva

Day 12 post-op

Suture removal Suture removal
MH re-instruction MH re-instruction

Monitoring of the result

Harmonization of the gingiva line obvious after 6 months

Harmonization of the gingiva line obvious after 6 months

Monitoring after 6 months

Monitoring after 6 months

Before and after

Baseline vs. 6 months result

Before
After
Enhancement of soft tissue by MCAT (modified coronally advanced tunnel) technique in combination with hyaluronic acid (HYADENT BG) and naturally cross-linked collagen membrane (Smartbrane)
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Case Provided By Prof. Dr. Anton Friedman (Chair and Head Department of Periodontology, School of Dentistry, Faculty of Health, University of Witten, Germany)

Baseline:

Baseline
Baseline

Modified tunnel preparation:

Modified tunnel preparation

Smartbrane (30 x 40 mm) (Regedent, Dettelbach Germany):

Smartbrane (30 x 40 mm)

Placement of the folded Smartbrane inside the tunnel with the sliding PTFE suture:

Placement of the folded Smartbrane inside the tunnel with the sliding PTFE suture Placement of the folded Smartbrane inside the tunnel with the sliding PTFE suture
Placement of the folded Smartbrane inside the tunnel with the sliding PTFE suture

Coronally advanced tunnel with the Smartbrane inside:

Coronally advanced tunnel with the Smartbrane inside

Suturing of the folded Smartbrane with 4.0 PTFE (BioTex, Regedent, Germany) and Monocryl 6.0 (Ethicon, HH, Germany):

Suturing of the folded Smartbrane with 4.0 PTFE (BioTex, Regedent, Germany) and Monocryl 6.0 (Ethicon, HH, Germany)

Follow up after 5 months of healing:

Follow up after 5 months of healing
Follow up after 5 months of healing
Deep Miller Class II Recession
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Case Provided By Prof Anton Sculean, Berne, Switzerland

1a. Baseline:

1a. Baseline

1b. Tunnel:

1b. Tunnel

2a. Mobilized Tunnel:

2a. Mobilized Tunnel

2b. Connective tissue graft (CTG):

2b. Connective tissue graft (CTG)

3a. Application of HYADENT BG:

3a. Application of HYADENT BG

3b. Applied HYADENT BG in the tunnel:

3b. Applied HYADENT BG in the tunnel

4a. Connective tissue graft fi xed in the tunnel:

4a. Connective tissue graft fi xed in the tunnel

4b. Application of HYADENT BG on the connective tissue graft:

4b. Application of HYADENT BG on the connective tissue graft

5a. Laterally closed tunnel:

5a. Laterally closed tunnel

5b. Outcome:

5b. Outcome
Treatment Of A Gingival Recession
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Case Provided By Prof Andrea Pilloni, Rome, Italy

PRE-OPERATIVE

A recession defect of Miller Class II was observed in the lower right canine despite the patient’s good dental hygiene and regular dental treatment.

PRE-OPERATIVE

SURGERY

The recession was treated surgically. After fl ap preparation, the root surface was carefully cleaned.

SURGERY

HYADENT BG was applied on to the root surface and incision areas of the soft tissue to support periodontal regeneration and fast wound healing (large image). HYADENT BG mixes well with blood, which is essential for the clinical effi cacy of hyaluronic acid (small image).

HYADENT BG was applied

The wound was closed with a Coronally Advanced Flap (CAF).

The wound was closed with a Coronally Advanced Flap (CAF)

1 YEAR POST-OPERATIVE

The recession remains well covered with healthy soft tissue.

1 YEAR POST-OPERATIVE
Hyaluronic acid in periodontal and bone tissue regeneration
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Case and article provided By Prof. Dr. Anton Friedman (Chair and Head Department of Periodontology, School of Dentistry, Faculty of Health, University of Witten, Germany)


Indicators GTR, GBR, hyaluronic acid, bone, fibrin, PRF, lateral augmentation, subcutaneous defect, regeneration, wound healing, human histology.

Summary: Hyaluronic acid (NA) corresponds to several important parameters and can be used to increase the success of restorative treatment in difficult situations. HA supports the condition of the wound without toxins, HA improves the stabilization of the wound, accelerates its healing and supports cellular processes during periodontal and bone regeneration. Two methods "Directed tissue regeneration" (GTR) and "Directed bone regeneration" (GBR) are used for regenerative treatment of periodontal and alveolar process defects. Conflicting results in the treatment of complex defects make it possible for a larger range of applications ON.

PNG Full article

Description

What shows that xHya (cross-linked hyaluronic acid) helps Guided Bone Regeneration?

xHya cross-linked hyaluronic acid

Better volume stability after 6 months with DBBM + xHyA

Mandibular median width (mm)

Kauffmann et al. (submitted)

Better volume stability after 6 months with DBBM + xHyA

Better volume stability after 2 months with DBBM + xHyA

Mandibular median width (mm)

Better volume stability after 2 months with DBBM + xHyA

Split mouth case of ridge preservationi


More bone cells, better DBBM remodelling, limited soft-tissue growth after 2 months with DBBM + xHyA

DBBM:

DBBM

DBBM + xHyA:

DBBM + xHyA

HYALURONIC ACID-EFFECTS

HYADENT BG HYALURONIC ACID

HYADENT BG, a highly concentrated and cross-linked hyaluronic acid gel, is designed specifically for the application in the dental field

Hyaluronic acid (HA), as one of main components of the extracellular matrix is naturally present in the human body1-3. Studies have shown that prolonged presence of HA during the healing process promotes healing by regeneration rather than reparation4,5.

Besides accelerating the healing of soft tissue and bone6,7,8, the bacteriostatic properties of HA also protect the wound9.

HYADENT BG remains present throughout the various phases of the healing process due to its slow degradation pattern (several weeks)10.

In addition, it aids the surgical periodontal treatment after application to the root surface and soft tissue.

This leads to faster wound closure, substantial pocket reduction and enhanced attachment11-13. When mixed with bone substitute material of any origin HYADENT BG forms an easily manageable putty, which may in addition lead to accelerated bone formation.14,15.

HYADENT BG is a hyaluronic acid-based treatment solution of non- animal origin optimized for regenerative dental and periodontal applications.

  • Accelerated tissue healing
    Coordinates the post-operative inflammation process and accelerates angiogenesis11,16,17
  • Improved outcome
    Stabilizes coagulum and supports tissue regeneration11-13,16
  • Improved predictability
    Bacteriostatic action and reduced pathogen penetration9

Principle of operation

  1. Attracts blood
  2. Stabilizes coagulum and supports tissue regeneration
  3. Bacteriostatic effect provides protection
  4. Growth factors attracted by hyaluronic acid
  5. Coordinates inflammation and accelerates angiogenesis
Hyaluronic acid-mode of action

Video

References

Literature
  1. Lee JY, Spicer AP. ‘Hyaluronan: a multifunctional, megadalton, stealth molecule.’ Curr Opin Cell Biol 2000;12:581–586.
  2. McDonald J, Hascall VC. ‘Hyaluronan mini review series.’ JBiol Chem 2002; 277:4575–4579.
  3. Jiang D et al. ‘Hyaluronan as an immune regulator in human diseases.’ Physiol Rev 2011;91:221–264.
  4. Longaker T et al. ‘Studies in Fetal Wound Healing: V. A prolonged presence of hyaluronic acid characterizes fetal wound healing’ Ann. Surg. 1991; April:292–296.
  5. Mast BA et al. ‘Hyaluronic Acid Modulates Proliferation, Collagen and Protein Synthesis of Cultured Fetal Fibroblast’ Matrix, 1993;13:441–446
  6. Salbach J et al. ‘Regenerative potential of glycosaminoglycans for skin and bone.’ J Mol Med 2012;90:625–635.
  7. Muzaffer A. et al. ‘The Effect of Hyaluronic Acid-supplemented Bone Graft in Bone Healing: Experimental Study in Rabbits ’ J Biomater Appl 2006 20:209
  8. Sasaki T, Watanabe C, Bone. Vol. 16. No.1 January 1995:9-15
  9. Pirnazar P. et al. ’Bacteriostatic effects of hyaluronic acid.’ Journal of Periodontology 1999;70:370-374
  10. De Boulle K, Glogau R, Kono T, et al. ‚A Review of the Metabolism of 1,4-Butanediol Diglycidyl Ether– Crosslinked Hyaluronic Acid Dermal Fillers.’ Dermatologic Surgery 2013;39(12):1758-1766
  11. King SR, Hickerson WL, Proctor KG. Benefi cial actions of exogenous hyaluronic acid on healing. Surgery 1991;109(1):76-84
  12. Fawzy ES. et al. Local application of hyaluronan gel in conjunction with periodontal surgery: a randomized controlled trial. Clin Oral Invest 2012;16:1229-1236
  13. Briguglio, F. et al. Treatment of infrabony periodontal defects using a resorbable biopolymer of hyaluronic acid: A randomized clinical trial. Quintessence Int 2013;44:231-240
  14. Stiller M. et al. ‘Performance of β-tricalcium phosphate granules and putty, bone grafting materials after bilateral sinus fl oor augmentation in humans’ Biomaterials 2014;35(10):3154-3163.
  15. Mendes RM et al. ‘Sodium hyaluronate accelerates the healing process in tooth sockets of rat’ Arch Oral Biol 2008; 53:1155–1162
  16. Kessiena L. Aya et al. ‘Hyaluronan in wound healing: Rediscovering a major player.’ Wound Rep Reg 2014;22:579-593. Dental Journal. (2017) Vol.42:104-11.
  17. West DC et al. ‘Angiogenesis induced by degradation products of hyaluronic acid.’ Science. 1985 Jun 14;228(4705):1324-6.
HYADENT BG is a registered brand and manufactured by BioScience GmbH, Walsmühler Str. 18, 19072 Dümmer, Germany CE certifi ed medical device, class III Art. 8161.901EN, Version 2019

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KEYWORDS RU hyadent bg, регенерация тканей
Terms of delivery Delivery Is free of charge within 24 hours after funds are credited to your Bank account
In StockIn Stock
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