SMARTBRANE. Resorbable Pericardium Membrane | PARADENT
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SMARTBRANE


Description:

Resorbable Pericardium Membrane

SMARTBRANE is a resorbable collagen membrane made from porcine pericardium. Thus, it features all benefits of a modern native collagen membrane.

In addition to the standard membrane sizes, it is available in a mini format of 10 x 10 mm. This offers a more economic membrane solution especially for regeneration of small bone defects optimizing your cost-benefit structure.

Other product options:
Characteristic:
KEYWORDS RU
коллагеновая мембрана, smartbrane, рассасывающаяся мембрана, мембрана из перикарда
Size of the membranes
10x10 mm
Terms of delivery Delivery Is free of charge within 24 hours after funds are credited to your Bank account
In StockIn Stock

Clinical cases

Enhancement of soft tissue by MCAT (modified coronally advanced tunnel) technique in combination with hyaluronic acid (HYADENT BG) and naturally cross-linked collagen membrane (Smartbrane)
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Case Provided By Prof. Dr. Anton Friedman (Chair and Head Department of Periodontology, School of Dentistry, Faculty of Health, University of Witten, Germany)

Baseline:

Baseline
Baseline

Modified tunnel preparation:

Modified tunnel preparation

Smartbrane (30 x 40 mm) (Regedent, Dettelbach Germany):

Smartbrane (30 x 40 mm)

Placement of the folded Smartbrane inside the tunnel with the sliding PTFE suture:

Placement of the folded Smartbrane inside the tunnel with the sliding PTFE suture Placement of the folded Smartbrane inside the tunnel with the sliding PTFE suture
Placement of the folded Smartbrane inside the tunnel with the sliding PTFE suture

Coronally advanced tunnel with the Smartbrane inside:

Coronally advanced tunnel with the Smartbrane inside

Suturing of the folded Smartbrane with 4.0 PTFE (BioTex, Regedent, Germany) and Monocryl 6.0 (Ethicon, HH, Germany):

Suturing of the folded Smartbrane with 4.0 PTFE (BioTex, Regedent, Germany) and Monocryl 6.0 (Ethicon, HH, Germany)

Follow up after 5 months of healing:

Follow up after 5 months of healing
Follow up after 5 months of healing
Augmentation of a dehiscence-type defect around dental implant
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Clinical pictures by courtesy Dr. Kai Fischer (Germany).

Surgery. Dehiscence defect around bone level implant.

Surgery

Augmentation with xenograft bone.

Augmentation with xenograft bone

Coverage of bone graft material with SMARTBRANE – the membrane can easily be positioned and adapts ideally to the defect geometry.

Coverage of bone graft material with SMARTBRANE

Suture removal. Optimal initial healing pattern: no signs of irritation.

Suture removal

Description

SMARTBRANE: Resorbable Pericardium Membrane

More economic

10 x 10 mm – big enough to cover small defects


Simple

SMARTBRANE: Resorbable Pericardium Membrane

Optimized handling properties ensuring straight-forward application

The supercritical carbon dioxide (scCO2) cleaning process gently removes unwanted materials (e.g., cells, lipids) while preserving the natural collagen matrix and optimizing the natural cross-linking of the collagen fibers.1,2

As a result, SMARTBRANE is characterized by optimal material stability as the biomechanical characteristics of porcine pericardium tissue are preserved.3.

SMARTBRANE...

  • Adequate tensile strength;
  • Adaptable to bony surfaces without sticking to the graft or instrument;
  • Less than 0.4 mm thin for facilitated augmentation and wound closure.
SMARTBRANE: Resorbable Pericardium Membrane

SMARTBRANE rehydrated: excellent adaptation to surfaces without sticking to graft or instrument.


Reliable

Natural collagen matrix preserved by scCO2 cleaning technology for enhanced graft performance

SMARTBRANE is made from porcine pericardium thus presenting optimal matrix composition and a naturally dense 3D-network collagen structure optimally preserved after scCO2 purification.

The preserved natural collagen matrix plays an important role in blood clotting and promotes cell attachment.5

The membrane has a resorption time of 8–12 weeks providing adequate barrier function for usage in standard GBR cases.6

SMARTBRANE cross-section

SMARTBRANE cross-section (magnification x 40) featuring intact structure and a natural interconnective porous system.


Pure

Excellent biocompatibility for improved wound healing.

SMARTBRANE is manufactured using an innovative and highly effective cleaning technology based on supercritical carbondioxide (scCO2).

This process results in a high purity and creates a biocompatible base for immediate new bone ingrowth.1,2

It provides highest possible biocompatibility characteristics due to its porcine origin and the scCO2 cleaning process.

Histological examination in vivo4

Histological examination in vivo. One week after

One week after subcutaneous implantation in a rat muscle: SMARTBRANE (M) is already connected to the muscular tissue (MT), no signs of inflammatory reactions.

Histological examination in vivo. Two week after

Two weeks after implantation: the first blood vessels (BV) are sprouting into SMARTBRANE (M), no signs of inflammatory reactions.


Technology

scCO2 cleaning process as basis for optimal matrix properties and maximal graft safety

STEP 1

scCO2 Processing

STEP 2

Chemical Treatment

STEP 3

Freeze-Drying

STEP 4

ɣ-Sterilization

STEP 1

Supercritical Carbon Dioxide (scCO2) Processing

  • Carbon dioxide is in its supercritical state when both the temperature and pressure equal or exceed the critical point of 31°C and 73 atm.
  • In this supercritical state, CO2 has both gas-like and liquid-like qualities.
  • By its effective tissue perfusion and removing capabilities of unwanted substances it provides ideal conditions for cleaning and sterilizing tissues1,2.
  • Additionally, scCO2 is known to be highly efficient against all kinds of pathogens7.

STEP 2

Chemical Treatment

  • Various chemical treatment steps are applied to provide a pure membrane matrix by inactivating and removing residual non-collagenous proteins and enzymes. This results in a further increased safety level for pathogen inactivation.8.

STEP 3

Freeze-Drying

  • Freeze-drying allows gentle preservation, retaining the original 3D structure of the native tissue.
  • After freeze-drying, products can be stored at room temperature and generally have a longer shelf life.

STEP 4

ɣ-Sterilization

  • The combination of the scCO2 cleaning process and terminal gamma-sterilization provides highest possible viral and bacterial inactivation and results in a sterile (SAL>10 -6) and highly biocompatible membrane.1,9

Video

References

  1. Nichols A, Burns DC, Christopher R. Studies on the Sterilization of Human Bone and Tendon Muscoskeletal Allograft Tissue Using Supercritical Carbon Dioxide. Journal of Orthopaedics 2009.
  2. Sawada K, Terada D, Yamaoka T, Kitamura S, Fujisato T. Cell removal with supercritical carbon dioxide for acellular artificial tissue. J Chemical Technol Biotechnol 2008;83(6):943–949.
  3. Internal testing results, data on file.
  4. SMARTBRANE subcutaneous implantation test, data on file.
  5. Brett D. A Review of Collagen and Collagen-based Wound Dressings. Wounds 2008;20(12).
  6. Internal testing results, data on file.
    1. Pages F, Poirier B, Barbier Y, Frayssinet P, Joffret M-L, Majewski W, Bonel G, Larzul D. Viral Inactivation of Human Bone Tissue using supercritical Fluid Extraction. ASAIO Journal 1998;44:289-293.
    2. Qiu QQ, Leamy P, Brittingham J, Pomerleau J, Kabaria N, Connor J. Inactivation of bacterial spores and viruses in biological material using supercritical carbon dioxide with sterilant. J Biomed Mater Res B Appl Biomater. 2009;91(2):572-8.
    3. Dillow AK, Dehghani F, Hrkach JS, Foster NR, Langer R. Bacterial inactivation by using near- and supercritical carbon dioxide. Proc Natl Acad Sci U S A. 1999;96(18):10344-8.
  7. Sofer G, Lister DC, Boose JA. Part 6, Inactivation Methods Grouped by Virus. BioPharmInternational 2003;6 Supplement:S37-S42.
  8. Thomas FC, Ouwerkerk T, McKercher P. Inactivation by gamma irradiation of animal viruses in simulated laboratory effluent. Appl Environ Microbiol. 1982;43(5):1051–1056.
Clinical pictures by courtesy Dr. Kai Fischer (Germany). Manufactured by REGEDENT AG, Zollikerstrasse 144, CH - 8008 Zürich CE0086 Art. 8121.900EN, Version 2015-11-13

Other
KEYWORDS RU коллагеновая мембрана, smartbrane, рассасывающаяся мембрана, мембрана из перикарда
Size of the membranes 10x10 mm
Terms of delivery Delivery Is free of charge within 24 hours after funds are credited to your Bank account
In StockIn Stock
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